PT  - JOURNAL ARTICLE
AU  - MacIntosh, B.J.
AU  - Lindsay, A.C.
AU  - Kylintireas, I.
AU  - Kuker, W.
AU  - Günther, M.
AU  - Robson, M.D.
AU  - Kennedy, J.
AU  - Choudhury, R.P.
AU  - Jezzard, P.
TI  - Multiple Inflow Pulsed Arterial Spin-Labeling Reveals Delays in the Arterial Arrival Time in Minor Stroke and Transient Ischemic Attack
AID  - 10.3174/ajnr.A2008
DP  - 2010 Nov 01
TA  - American Journal of Neuroradiology
PG  - 1892--1894
VI  - 31
IP  - 10
4099  - http://www.ajnr.org/content/31/10/1892.short
4100  - http://www.ajnr.org/content/31/10/1892.full
SO  - Am. J. Neuroradiol.2010 Nov 01; 31
AB  - Our purpose was to use multiple inflow pulsed ASL to investigate whether hemodynamic AAT information is sensitive to hemispheric asymmetry in acute ischemia. The cohorts included 15 patients with acute minor stroke or TIA and 15 age-matched controls. Patients were scanned by using a stroke MR imaging protocol at a median time of 74 hours. DWI lesion volumes were small and functional impairment was low; however, perfusion abnormalities were evident. Prolonged AAT values were more likely to reside in the affected hemisphere (significant when compared with controls, P < .048). An advantage of this ASL technique is the ability to use AAT information in addition to CBF to characterize ischemia. AATarterial arrival timeASLarterial spin-labelingAUHarea under the histogramCBFcerebral blood flowDSCdynamic susceptibility contrastDWIdiffusion-weighted imagingFMRIBFunctional MRI of the BrainGRASEgradient and spin-echoICAinternal carotid arteryMCAmiddle cerebral arteryNIHSSNational Institutes of Health Stroke ScalePASLpulsed arterial spin-labelingTIAtransient ischemic attack