RT Journal Article SR Electronic T1 Multimodality Imaging in Primary Progressive Aphasia JF American Journal of Neuroradiology JO Am. J. Neuroradiol. FD American Society of Neuroradiology SP 1230 OP 1243 DO 10.3174/ajnr.A7613 VO 43 IS 9 A1 M. Roytman A1 G.C. Chiang A1 M.L. Gordon A1 A.M. Franceschi YR 2022 UL http://www.ajnr.org/content/43/9/1230.abstract AB SUMMARY: Primary progressive aphasia is a clinically and neuropathologically heterogeneous group of progressive neurodegenerative disorders, characterized by language-predominant impairment and commonly associated with atrophy of the dominant language hemisphere. While this clinical entity has been recognized dating back to the 19th century, important advances have been made in defining our current understanding of primary progressive aphasia, with 3 recognized subtypes to date: logopenic variant, semantic variant, and nonfluent/agrammatic variant. Given the ongoing progress in our understanding of the neurobiology and genomics of these rare neurodegenerative conditions, accurate imaging diagnoses are of the utmost importance and carry implications for future therapeutic triaging. This review covers the diverse spectrum of primary progressive aphasia and its multimodal imaging features, including structural, functional, and molecular neuroimaging findings; it also highlights currently recognized diagnostic criteria, clinical presentations, histopathologic biomarkers, and treatment options of these 3 primary progressive aphasia subtypes.ADAlzheimer diseaseASLarterial spin-labelingFTLDfrontotemporal lobar degenerationlvPPAlogopenic variant PPAnfvPPAnonfluent/agrammatic variant PPAPPAprimary progressive aphasia3R3-repeat4R4-repeatsvPPAsemantic variant PPATDP-43transactive-response DNA-binding protein 43TSPOtranslocator protein 18 kDa