Demographic and cognitive clinical variables of the subjects included in this studya
| Cognitive Examination | First Follow-Up (n = 65) | Second Follow-Up (n = 32) |
|---|---|---|
| Age (mean) (range) (yr) | 36.5 (SD, 10.1) (21–62) | 45.9 (SD, 10.5) (29–61) |
| Sex (M/F) | 26:39 | 13:19 |
| DD (mean) (yr) | 15.0 (SD, 7.1) | 18.6 (SD, 7.7) |
| SDMT z score (mean) | –1.3 (SD, 1.2) | –1.1 (SD, 1.1) |
| BVMT z score (mean) | –0.9 (SD, 1.5) | –0.6 (SD, 1.4) |
| CVLT z score (mean) | –0.6 (SD, 1.4) | –0.4 (SD, 1.5) |
| BICAMS z score (mean) | –0.9 (SD, 1.1) | –0.7 (SD, 1.0) |
| FU time from baseline (mean) (yr) | 4.6 (SD, 1.0) | 7.5 (SD, 0.7) |
| ΔBICAMS (mean) | NA | –0.3 (SD, 0.8) |
| Cognitive impairment (impaired/preserved) | 40/25 | NA |
| Cognitive progression | NA | 5/32 (15.6%) |
Note:—FU indicates follow-up.
↵a Cognitive impairment at the first time point was defined if a subject showed at least one of the z score values of equal or less than –1.5. Cognitive worsening at second time point was defined in case of ΔBICAMS equal or less than –0.5.