Table 2:

Exploratory analysis of perfusion patterns for predicting time-to-progression in patients with glioblastoma

CEL (No. of voxels)	Time-to-Progression
CEL (No. of voxels)	HR^{^a}	95% CI	P Value
High angiogenic tumor (1)	0.13	0.01–4.59	.25
High angiogenic tumor (2)	4.74	0.01–231.7	.62
Low angiogenic/cellular tumor	0.99	0.10 –9.91	.99
Perinecrotic lesion	22.3	0.44–111.30	.11
CEL (%)
High angiogenic tumor (1)	0.71	0.20–2.51	.59
High angiogenic tumor (2)	0.65	0.21–2.04	.46
Low angiogenic/cellular tumor	2.14	0.33–14.03	.42
Perinecrotic lesion	2.67	0.52–13.63	.24
NEL (No. of voxels)
High angiogenic tumor (3)	0.95	0.29–3.06	.93
Low angiogenic/cellular tumor	2.18	1.01–12.57	.047
Infiltrated edema	1.88	1.35–2.78	.009
Vasogenic edema	1.04	0.71–1.52	.84
NEL
High angiogenic tumor (3)	0.25	0.21–5.31	.37
Low angiogenic/cellular tumor	0.41	0.08–1.99	.27
Infiltrated edema	2.14	0.40–11.35	.37
Vasogenic edema	4.20	0.52–33.98	.18

↵a HRs reported here indicate the relative change in hazard that a 1-U (10,000 voxels for the number of voxels and 1% for percentage) increase in each imaging parameter incurs.