Association of measures of continuous imaging features with variant histone H3–altered versus H3 wild-type tumors
| Imaging Metric | Any Histone Mutation | Wild-Type | P Valuea | ||
|---|---|---|---|---|---|
| No. | Median (Range) | No. | Median (Range) | ||
| ADC total (×10–6 mm2/s) | |||||
| Mean | 61 | 1302.42 (538.06–1797.58) | 12 | 1350.77 (922.96–1729.62) | .98 |
| Median | 61 | 1245 (532–1842) | 12 | 1345 (917–1781) | .97 |
| Mode | 61 | 1250.51 (450.92–1961.24) | 12 | 1305.29 (863.39–1805.47) | .9 |
| Skewness | 52 | 0.68 (−0.89–3.11) | 11 | 0.98 (−0.30–2.57) | .3 |
| Kurtosis | 52 | 1.4 (−0.78–15.62) | 11 | 2.82 (−0.78–10.77) | .1 |
| ADC_enhancement (×10–6 mm2/s) | |||||
| Mean | 45 | 1152.88 (689.44–1898.26) | 6 | 1199.86 (956.62–1723.18) | .7 |
| Median | 45 | 1142.00 (667–1890) | 6 | 1187.00 (807–1762) | .7 |
| Mode | 45 | 1062.49 (577.86–1746.86) | 6 | 1175.10 (719.70–1805.78) | .6 |
| Skewness | 43 | 0.86 (−0.85–4.73) | 6 | 0.67 (−0.14–1.86) | .7 |
| Kurtosis | 43 | 1.69 (−0.94–29.06) | 6 | 1.35 (0.098–12.45) | .9 |
| FLAIR/T2/T1 PG volume (×103 mm3) | |||||
| FLAIR/T2 | 60 | 35.13 (7.97–77.57) | 13 | 32.77 (10.13–79.62) | .8 |
| Enhancing | 46 | 1.96 (0.04–14.10) | 8 | 1.95 (0.01–4.71) | .4 |
↵a Wilcoxon rank-sum test.