Hemorrhage in PRES: relationship to clinical associations and blood pressure at toxicity
| Toxicity Association | Total No. Pts with PRES | Patients with PRES and Hemorrhage | |||
|---|---|---|---|---|---|
| No. Hemorrhage (%) | Blood Pressure in Pts with PRES Hemorrhage | ||||
| Normotensive (MAP ≤ 105) | Mild HTN (MAP, 106–115) | Severe HTN (MAP ≥ 116) | |||
| Immunosuppression‡ | 50 | 11 (22.0) | 3 | 1 | 7 |
| Solid-organ transplant | 34 | 4 (11.8) | 2 | 1 | 1 |
| Allo-BMT | 15 | 7 (46.7) | 1 | 0 | 6 |
| Other* | 1 | 0 (0.0) | – | – | – |
| Infection/sepsis/shock | 52 | 6 (11.5) | 4 | 1 | 1 |
| Autoimmune | 12 | 2 (16.7) | 0 | 0 | 2 |
| Chemotherapy | 10 | 1 (10.0) | 0 | 1 | 0 |
| Eclampsia† | 18 | 1 (5.6) | 0 | 0 | 1 |
| Unknown | 9 | 2 (22.2) | 0 | 0 | 2 |
| Total | 151 | 23 (15.2) | 7 | 3 | 13 |
Note:—Pts indicates patients; CsA, cyclosporine; HTN, hypertension; –, none; PRES, posterior reversible encephalopathy syndrome; MAP, mean arterial pressure; FK-506, tacrolimus; Allo-BMT, allogeneic bone marrow transplantation.
* A single patient with psoriasis on cyclosporine.
† Patients with eclampsia and delayed eclampsia.
‡ Transplant, on cyclosporine, or tacrolimus (FK-506).