Comparison of descriptive data in patients with SCD and control subjects without controlling for age
| Comparison | Patients (n = 83)* | Controls (n = 43)* | % Difference | P value† |
|---|---|---|---|---|
| Subject age (y) | 9.36 ± 3.83 | 10.02 ± 3.61 | −6.40 | NS |
| Proportion male (%) | 56.6 | 58.1 | −2.60 | NS |
| Volume (mL) | ||||
| Total brain | 94.72 ± 8.11 | 97.24 ± 6.10 | −2.60 | .04 |
| White matter | 27.16 ± 4.55 | 27.52 ± 4.59 | −1.30 | NS |
| Gray matter | 61.30 ± 6.10 | 63.99 ± 5.18 | −4.20 | .01 |
| Central gray matter | 10.60 ± 1.46 | 11.32 ± 1.51 | −6.40 | .01 |
| Cortical gray matter | 50.96 ± 4.37 | 52.58 ± 4.59 | −3.10 | .03 |
| CSF | 6.26 ± 2.55 | 5.73 ± 1.90 | 9.20 | NS |
Note.—NS indicates not significant. Age did not differ significantly between patients and controls, so this approach may be valid.
* Data are mean ± SD.
† Statistical testing was performed with a two-sample t test.