TABLE 3:

Least-squares means of brain volumes between the 83 patients with SCD and 43 control subjects as a function of age

Volume and Group	5.0 Years Old	P Value	9.5 Years Old	P Value	11.50 Years	P Value
Total brain
Control	98.29 ± 1.94	.0127	97.35 ± 1.13	NS	96.93 ± 1.21	NS
SCD	92.49 ± 1.22		94.79 ± 0.80		95.82 ± 0.92
White matter
Control	26.63 ± 1.16	NS	27.43 ± 0.68	NS	27.79 ± 0.72	NS
SCD	25.25 ± 0.72		27.22 ± 0.48		28.10 ± 0.55
Gray matter
Control	67.47 ± 1.50	.0004	64.35 ± 0.87	.0052	62.96 ± 0.94	NS
SCD	61.07 ± 0.94		61.30 ± 0.62		61.41 ± 0.71
Central gray matter
Control	11.98 ± 0.38	.0014	11.39 ± 0.22	.0045	11.13 ± 0.24	NS
SCD	10.51 ± 0.24		10.60 ± 0.16		10.64 ± 0.18
Cortical gray matter
Control	55.54 ± 1.14	.0021	52.89 ± 0.67	.0195	51.71 ± 0.72	NS
SCD	51.29 ± 0.72		50.95 ± 0.48		50.80 ± 0.54
CSF
Control	4.18 ± 0.61	.0067	5.56 ± 0.36	NS	6.18 ± 0.38	NS
SCD	6.17 ± 0.38		6.27 ± 0.26		6.31 ± 0.29