Linear regression analysis results

	Block 1 Covariates	Retained MRI Variables	Partial r for primary predictor	Change in R² from Block 1	Mulitple R²	P Value
Processing Speed and Working Memory
Paced Auditory Serial Addition Test	Age	LVV	0.42	0.16	0.17	.030
	Age, BDI	LVV	0.47	0.21	0.22	.020
Symbol Digit Modalities Test	Age	LVV; Left Parietal	0.63	0.32	0.50	.001
	Age, BDI	Left Temporal; BPF; Right Temporal	0.64	0.31	0.61	.001
Auditory/Verbal Learning and Recent Memory
CVLT-II Total Learning	Age	Left Temporal	0.55	0.17	0.30	.006
	Age, BDI	Left Temporal	0.57	0.17	0.32	.014
CVLT-II Delayed Recall	Age	Left Temporal; Left Occipital	0.56	0.15	0.45	.001
	Age, BDI	Left Temporal; Left Occipital	0.61	0.20	0.50	.001
Visual/Spatial Learning and Recent Memory
BVMT-R Total Learning	Age	—	0.31
	Age, BDI	Left Temporal; Right Temporal	0.51	0.18	0.48	.001
BVMT-R Delayed Recall	Age	Left Temporal; Right Temporal	0.62	0.22	0.58	<.001
	Age, BDI	Left Temporal; Right Temporal	0.67	0.29	0.59	.001
Consistency of Learning
CVLT-II Learning Consistency	Age	Left Frontal	0.44	0.17	0.19	.030
	Age, BDI	Left Frontal	0.44	0.16	0.20	.030
BVMT-R Learning Consistency	Age	Left Temporal	0.66	0.29	0.43	<.001
	Age, BDI	Left Temporal; Left Frontal	0.68	0.31	0.55	<.001

Note.—For each regression model, table shows the partial r between the first predictor controlling for variables entered in block 1 and the change in R² after block 1. CVLT-II = California Verbal Learning Test second edition, BVMT-R = Brief Visuospatial Memory Test-Revised, BDI = Beck Depression Inventory, LVV = Lateral Ventricle Volume, BPF = Brain Parenchyma Fraction. Lobar region labels reflect regional brain parenchyma fractions.