Angiographic characteristics of treatment groups
| Reteplase (n = 33) | Urokinase (n = 22) | |
|---|---|---|
| Mean age, y (median, range) | 63 ± 13 (64, 36–88) | 60 ± 15 (62, 25–83) |
| Median NIHSS (range) | 16 (5–25, 81% ≥10) | 17 (6–38, 85% ≥10) |
| Occlusion territory | ||
| ICA | 7 (21%) | 4 (18%) |
| Location | 4 distal (3 “T” occlusions), 3 proximal | 3 distal (3 “T” occlusions), 1 proximal |
| Etiology | 3 thrombotic, 3 embolic, 1 unknown | 2 embolic, 2 unknown |
| MCA | 17 (52%) | 9 (41%) |
| Location | 10 M-1, 7 M-2 | 6 M-1, 3 M-2 |
| Etiology | 5 thrombotic, 11 embolic, 1 unknown | 4 thrombotic, 5 embolic |
| BA | 9 (27%) | 9 (41%) |
| Location | 6 proximal, 2 middle, 1 distal | 6 proximal, 1 middle, 2 distal |
| Etiology | 4 thrombotic, 4 embolic, 1 unknown | 1 thrombotic, 8 embolic |
| Mean, median, and range of time from stroke onset to IA treatment (minutes) | 333 + 230 (285, 148–1195) | 343 + 169 (305, 133–720) |
| Mean total IA thrombolytic dose | 2.5 ± 1.36 mg (2, 1–6) | 690,000 ± 562,000 U (575,000, 50,000–1,500,000) |
| Mechanical thrombolysis | ||
| Simple wire | 6 (1 BA, 4 MCA, 1 ICA) | 3 (1 MCA, 2 ICA) |
| PTA | 11 (2 BA, 8 MCA, 1 ICA) | 0 |
| PTA + stent | 2 (1 MCA, 1 ICA) | 2 (1 BA, 1 ICA) |
Note:—NIHSS indicates National Institutes of Health Stroke Scale; IA, intra-arterial; PTA, percutaneous transluminal angioplasty; BA, basilar artery; MCA, middle cerebral artery; ICA, internal carotid artery.