Table 4:

Spearman rank correlation (ρ) values between visual score of LA, brain volumes, MD and FA histogram metrics, and motor and neuropsychologic scores

VariableSPPBUsual Gait Velocity, m/sSingle-Leg Stance Time, sMMSEStroop TestTrail-Making TestMaze TaskDigitVerbal Fluency
Fazekas scale−0.18−0.15−0.26−0.190.130.080.11−0.23−0.28
Normalized brain volume0.380.02−0.22−0.05−0.09−0.08−0.180.15−0.04
Gray matter−0.01−0.11−0.11−0.10−0.140.070.17−0.100.06
White matter0.280.26−0.04−0.020.02−0.14−0.290.24−0.05
Whole-brain MD
    25th percentile−0.21−0.32−0.48−0.280.510.300.32−0.30−0.46
(P = .006)(P = .001)(P = .004)
    50th percentile−0.15−0.20−0.35−0.160.540.310.30−0.31−0.44
(P < .001)(P = .007)
    Skewness−0.280.340.160.34−0.23−0.42−0.440.450.13
(P = .008)(P = .006)
    Kurtosis0.240.250.160.35−0.17−0.37−0.380.400.06
Whole-brain FA
    25th percentile−0.02−0.00−0.01−0.24−0.11−0.01−0.17−0.080.10
    50th percentile0.04−0.100.09−0.18−0.17−0.06−0.090.010.17
    Skewness−0.18−0.35−0.21−0.150.260.140.18−0.28−0.41
    Kurtosis−0.22−0.39−0.27−0.210.320.180.21−0.32−0.46
(P = .005)
  • Note:—LA indicates leukoaraiosis; MD, mean diffusivity; FA, fractional anisotropy; SPPB, Short Physical Performance Battery; MSSE, Mini Mental State Examination.