Spearman rank correlation (ρ) values between visual score of LA, brain volumes, MD and FA histogram metrics, and motor and neuropsychologic scores
| Variable | SPPB | Usual Gait Velocity, m/s | Single-Leg Stance Time, s | MMSE | Stroop Test | Trail-Making Test | Maze Task | Digit | Verbal Fluency |
|---|---|---|---|---|---|---|---|---|---|
| Fazekas scale | −0.18 | −0.15 | −0.26 | −0.19 | 0.13 | 0.08 | 0.11 | −0.23 | −0.28 |
| Normalized brain volume | 0.38 | 0.02 | −0.22 | −0.05 | −0.09 | −0.08 | −0.18 | 0.15 | −0.04 |
| Gray matter | −0.01 | −0.11 | −0.11 | −0.10 | −0.14 | 0.07 | 0.17 | −0.10 | 0.06 |
| White matter | 0.28 | 0.26 | −0.04 | −0.02 | 0.02 | −0.14 | −0.29 | 0.24 | −0.05 |
| Whole-brain MD | |||||||||
| 25th percentile | −0.21 | −0.32 | −0.48 | −0.28 | 0.51 | 0.30 | 0.32 | −0.30 | −0.46 |
| (P = .006) | (P = .001) | (P = .004) | |||||||
| 50th percentile | −0.15 | −0.20 | −0.35 | −0.16 | 0.54 | 0.31 | 0.30 | −0.31 | −0.44 |
| (P < .001) | (P = .007) | ||||||||
| Skewness | −0.28 | 0.34 | 0.16 | 0.34 | −0.23 | −0.42 | −0.44 | 0.45 | 0.13 |
| (P = .008) | (P = .006) | ||||||||
| Kurtosis | 0.24 | 0.25 | 0.16 | 0.35 | −0.17 | −0.37 | −0.38 | 0.40 | 0.06 |
| Whole-brain FA | |||||||||
| 25th percentile | −0.02 | −0.00 | −0.01 | −0.24 | −0.11 | −0.01 | −0.17 | −0.08 | 0.10 |
| 50th percentile | 0.04 | −0.10 | 0.09 | −0.18 | −0.17 | −0.06 | −0.09 | 0.01 | 0.17 |
| Skewness | −0.18 | −0.35 | −0.21 | −0.15 | 0.26 | 0.14 | 0.18 | −0.28 | −0.41 |
| Kurtosis | −0.22 | −0.39 | −0.27 | −0.21 | 0.32 | 0.18 | 0.21 | −0.32 | −0.46 |
| (P = .005) |
Note:—LA indicates leukoaraiosis; MD, mean diffusivity; FA, fractional anisotropy; SPPB, Short Physical Performance Battery; MSSE, Mini Mental State Examination.