Quantitative 1H-MR spectroscopy at 6 years 5 months and 6 years 11 months of age
| 2nd MR Imaging | 3rd MR Imaging | Normative | |
|---|---|---|---|
| White matter | |||
| NAA | 1.77 | 2.13 | 6.9 ± 0.6 |
| Cr | 4.81 | 4.81 | 4.9 ± 0.4 |
| Cho | 1.87 | 1.83 | 1.6 ± 0.3 |
| Gray matter | |||
| NAA | 4.73 | 5.02 | 8.3 ± 0.8 |
| Cr | 6.97 | 6.53 | 7.6 ± 0.6 |
| Cho | 1.85 | 2.46 | 1.9 ± 0.2 |
Note:—NAA indicates N-acetylaspartate; Cr, creatine; Cho, choline. Metabolite concentrations are μmol/L. NAA concentrations are significantly reduced in the white and central gray matter; Cho and Cr concentrations are normal. Normative age-matched regional values were derived from Pouwels et al.11