Metabolite Ratio | Control Group (n = 10) | Neonatal Encephalopathy Group (n = 17) | P Values | |||
---|---|---|---|---|---|---|
Normal/Mild Outcome (n = 10) | Severe/Fatal Outcome (n = 7) | Control Versus Normal/Mild Outcome | Control Versus Severe/Fatal Outcome | Normal/Mild Outcome Versus Severe/Fatal Outcome | ||
Lac/Cr | 0.38 (0.10) | 0.41 (0.13) | 0.70 (0.45β2.65) | .61 | .04* | .06 |
Lac/NAA | 0.24 (0.06) | 0.29 (0.09) | 0.54 (0.35β2.66) | .11 | .02* | .03* |
Lac/Cho | 0.15 (0.03) | 0.19 (0.05) | 0.32 (0.22β1.26) | .06 | .02* | .04* |
NAA/Cr | 1.59 (0.19) | 1.41 (0.28) | 1.16 (0.14) | .09 | <.001* | .04* |
NAA/Cho | 0.66 (0.08) | 0.67 (0.09) | 0.56 (0.11) | .73 | .04* | .04* |
Cho/Cr | 2.47 (0.57) | 2.10 (0.31) | 2.12 (0.36) | .09 | .17 | .91 |
Note:βLac indicates lactate; NAA, N-acetylaspartate; Cho, choline; Cr, creatine.
* Denotes statistically significant differences between the groups. Values are mean (SD) and median (interquartile range) as appropriate.