GM and WM peak height of the frontal, parietal, temporal, and occipital lobes
| Lobe | Tissue | Normal Cognition (n = 43) | MCI (n = 19) | AD (n = 55)a |
|---|---|---|---|---|
| Frontal | GM | 69.8 (±13.0) | 57.4 (±14.7)a | 53.2 (±11.0) |
| WM | 161.6 (±20.0) | 140.3 (±28.1)a | 135.7 (±24.3) | |
| Parietal | GM | 69.5 (±14.4) | 59.5 (±15.5) | 55.4 (±10.7) |
| WM | 167.5 (±23.2) | 145.6 (±26.8)a | 146.2 (±24.9) | |
| Temporal | GM | 82.3 (±12.8) | 68.8 (±11.4)a | 62.2 (±9.2) |
| WM | 144.4 (±19.3) | 126.8 (±25.0)a | 126.9 (±18.0) | |
| Occipital | GM | 80.0 (±16.4) | 75.7 (±10.0) | 68.3 (±9.5) |
| WM | 143.9 (±22.7) | 125.0 (±24.1)a | 126.9 (±18.0) |
Note:—Data are represented as mean (± SD). The peak height of the histogram was determined as a measure of the frequency of appearance in the most common MTR value and reflects the amount of remaining normal brain tissue (×103).
a Differs from the group with normal cognition (P < 0.01).