Clinical features of patients with SCA1 and SCA2
| Features | SCA1 (n = 14) | SCA2 (n = 11) |
|---|---|---|
| CAG repeats (range) | 40–58 | 35–47 |
| Age at onset (years) | 40.3 ± 10 | 35.9 ± 10 |
| Disease duration (years) | 8.2 ± 4.9 | 7.4 ± 4.4 |
| Dysarthria (%) | 100 | 87 |
| Nystagmus (%) | 21 | 0 |
| Vertical gaze palsy (%) | 43 | 73 |
| Horizontal gaze palsy (%) | 14 | 33 |
| Slow saccades (%) | 36 | 87 |
| Increased bicep reflexes (%) | 93 | 20 |
| Increased patellar reflexes (%) | 100 | 20 |
| Lower limb spasticity (%) | 71 | 13 |
| Babinski sign (%) | 79 | 60 |
| Decreased vibration sense (%) | 83 | 87 |
| Dysphagia (%) | 50 | 80 |
| Amyotrophy (%) | 7 | 0 |
| Cognitive impairment (%) | 7 | 13 |
| Sphincteric disturbances (%) | 29 | 47 |
Note:—CAG indicates cytosine adenine guanine.