Validation of eTCCD in comparison with DSA by analyzing the sensitivities, specificities, and positive and negative predictive values of the distinct arterial segments
| Segment | Sensitivity | Specificity | PPV | NPV |
|---|---|---|---|---|
| M1 | 87 (81–94) | 98 (96–99) | 92 (87–97) | 96 (94–98) |
| M2 | 76 (62–87) | 100 (100–100) | 100 (91–100) | 95 (92–97) |
| C1 | 84 (75–91) | 99 (99–100) | 97 (90–100) | 96 (94–98) |
| A1 | 77 (71–84) | 97 (94–99) | 94 (91–98) | 85 (81–89) |
| A2 | 70 (35–93) | 100 (100–100) | 100 (59–100) | 99 (97–100) |
| P1 | 74 (64–83) | 99 (98–100) | 96 (88–99) | 92 (89–95) |
| P2 | 77 (64–88) | 99 (98–100) | 93 (81–99) | 96 (94–98) |
| PComA | 91 (81–97) | 79 (68–88) | 78 (66–87) | 92 (82–97) |
| AComA | 94 (86–98) | 86 (42–100) | 98 (92–100) | 60 (26–88) |
| V4 | 78 (64–89) | 99 (97–100) | 92 (79–98) | 96 (93–98) |
| BA | 76 (50–93) | 99 (97–100) | 87 (60–98) | 97 (94–100) |
Note:—PPV indicates positive predictive value; NPV, negative predictive value; PComA, posterior communicating artery; AComA, anterior communicating artery; M1/M2, M1-/M2-segment of the middle cerebral artery; C1, C1-segment of the internal carotid artery; A1/A2, A1-/A2-segment of the anterior cerebral arteries; P1/P2, P1-/P2-segment of the posterior cerebral artery; V4, V4-segment of the vertebral artery; BA, basilar artery; eTCCD, echo-enhanced transcranial color-coded duplex sonography; DSA, digital subtraction angiography. The displayed values refer to the datasets obtained by both reviewers. All values are shown as percentages. Numbers in parentheses represent 95% confidence intervals.