Demographics, flow, and MR imaging characteristics of the study population
| MC (n = 25) | NonMC (n = 13) | |||
|---|---|---|---|---|
| Baseline | Follow-up | Baseline | Follow-up | |
| Demographics | ||||
| Male/female | 11/14 | 11/14 | 7/6 | 7/6 |
| Age (SD), years | 42.2 (10) | 49.4 (10) | 36.7 (8) | 43.8 (8) |
| Flow parameters | ||||
| TCBF in mL/min (SD) | 588 (128)† | − | 750 (179) | − |
| Cerebrovascular reactivity in % (SD) | 67 (20) | − | 68 (23) | − |
| MR imaging parameters | ||||
| WMH volume in % (SD) | 5.0 (3.9)† | 7.4 (5.3)** | 0.0 | 0.0 |
| Infarct count (range) | 6.2 (0–27)† | 9.9 (0–38)** | 0 | 0 |
| Microbleed count (range) | 1.6 (0–35) | 3.2 (0–40)* | 0 | 0 |
Note:—MC indicates mutation carriers; NonMC, nonmutation carriers; TCBF, total cerebral blood flow; WMH, white matter hyperintensities. The 2-sample ttest is used for comparisons of age, TCBF, and CVR. The Mann-Whitney U test is used for baseline comparisons of WMH volume, infarcts, and microbleeds. The χ2 test is used for male/female. CVR data are based on measurements in 14 MCs and 9 nonMCs.
* Difference (P < .05) between baseline and follow-up.
** Difference (P < .01) between baseline and follow-up.
† Difference (P < .01) between MCs and nonMCs at baseline.