Cervical cord atrophy and lesion MR imaging measures in normal control subjects and multiple sclerosis patients, according to disease type
| Variable | NC (n= 19), Mean (SD) | MS (n= 66), Mean (SD) | CIS (n= 11), Mean (SD) | RR (n= 34), Mean (SD) | SP (n= 14), Mean (SD) | PP (n= 7), Mean (SD) |
|---|---|---|---|---|---|---|
| CCAV, mm3 | 7691.7 (1136.2) | 7063.2 (1206.8)** | 7461.1 (599.5) | 7281.6 (758.9) | 5990.7 (1060.9)*** | 6907.3 (1796.2)* |
| CCF | 0.343 (0.29) | 0.318 (0.23)** | 0.344 (0.04) | 0.307 (0.06) | 0.307 (0.06)* | 0.294 (0.04)* |
| CCAV/ICV | 0.012 (0.002) | 0.016 (0.02) | 0.012 (0.002) | 0.015 (0.005) | 0.015 (0.016) | 0.01 (0.005) |
| Cervical T2-LV, mL | NA | 4.6 (5.8) | 0.7 (0.02) | 4.2 (3.8) | 9.7 (8) | 2.6 (3.2) |
Note:—NC indicates normal control subject; MS, multiple sclerosis; RR, relapsing-remitting; SP, secondary-progressive; PP, primary-progressive; CIS, clinically isolated syndrome; CCAV, cervical cord absolute volume; CCF, cervical cord fraction; CCAV/ICV, cervical cord absolute volume to intracranial volume; LV, lesion volume; NA, nonapplicable. A general linear model analysis was performed to test significant differences between normal control subjects and multiple sclerosis patients in which the age was entered as a covariate and, due to the multiple comparisons, a post hoc Bonferroni correction was applied directly in the SPSS analysis model.
P values are provided between normal control subject and multiple sclerosis patients
* P < .05;
** P < .01;
*** P < .001.