Interval to treatment and clinical outcome compared with previous studies
| Treatment | Occlusion Site | No. Patients (Treated†/Enrolled) | Intervals (min) | mRS 0, 1 (90 days) (%) | sICH (36 hours) (%) | Mortality (90 days) (%) | |||
|---|---|---|---|---|---|---|---|---|---|
| Onset to IV | Onset to ET | IV to ET | |||||||
| Current series | IV + IA (+ PTA) | M1, M2 | 16/29 | 110 | 150 | 40 | 63 | 0 | 6 |
| NINDS Part 2 (1995)1 | IV | us | 168 | 119 | − | − | 39 | 6.4 | 17 |
| PROACT II (1999)4 | IA | M1, M2 | 108/121 | − | 318 | − | 26 | 10 | 25 |
| Ernst et al (2000)6 | IV + rescue IA | I, M, A | 16/20 | 122 | 210 | 88 | 38‡ | 5 | 13‡ |
| IMS–I (2004)9 | IV + rescue IA | I, M, A, V, B | 62/80 | 136 | 217 | 81 | 29‡ | 6.3 | 14‡ |
| Lee et al (2004)10 | IV + rescue IA (+ abciximab IV) | I, M, P, B | 16/30 | 135 | (230*) | (95*) | 50‡ | 0 | 0‡ |
| Multi MERCI (2006)14 | IV + rescue thrombectomy (+ IA) | I, M, V, B | 30/111 | na | 216 | na | (33§) | 6.7 | 27 |
Note:—M indicates middle cerebral artery (MCA); M1, M1 segment of MCA; M2, M2 segment of MCA; I, internal carotid artery; A, anterior cerebral artery; P, posterior cerebral artery; V, vertebral artery; B, basilar artery; ET, endovascular therapy; sICH, symptomatic intracerebral hemorrhage; us, unspecified; na, not available; PTA, percutaneous transluminal angioplasty; NINDS, National Institute of Neurological Disorders and Stroke; PROACT, Prolyse in Acute Cerebral Thromboembolism; IMS, Interventional Management of Stroke; MERCI, Mechanical Embolus Removal in Cerebral Ischemia; IV, intravenous; IA, intra-arterial; mRS, modified Rankin Scale.
* Interval to angiography.
† No. of patients treated by combined therapy.
‡ Percentage in cases of MCA (M1 or M2) occlusion treated with combined therapy.
§ Percentage of mRS 0–2.