Clinical and imaging characteristics associated with hemorrhagic transformation
| Characteristic | HT on Follow-up Image | P value | |
|---|---|---|---|
| Yes | No | ||
| Number, N | 8 | 35 | |
| Age (yr), median (range) | 61 (42–78) | 69 (40–90) | .25 |
| History of diabetes, n (%) | 2 (25) | 7 (20) | 1.00 |
| Baseline NIHSS score, median (range) | 31 (11–40) | 18 (0–40) | .005* |
| GCS, median (range) | 4 (3–15) | 11 (3–15) | .012* |
| Onset-to-CTA (hrs), median (range) | 6.2 (1–24) | 4.6 (0.7–24) | .85 |
| Any thrombolysis, n (%) | 8 (100) | 27 (77) | .32 |
| IV lysis, n (%) | 8 (100) | 20 (57) | .036* |
| IA therapy, n (%) | 7 (88) | 22 (63) | .24 |
| Combined IV/IA therapy, n (%) | 7 (88) | 15 (43) | .046* |
| Onset-to-treatment (hrs), median (range) | 5.5 (1.9–24) | 4.2 (1.9–18.2) | .21 |
| Recanalization ≤ 24 hrs, n/N (%) | 4/7 (57) | 17/23 (74) | .33 |
| Pc-ASPECTS score on NCCT, median (range) | 8 (5–10) | 9 (5–10) | .11 |
| Pc-ASPECTS score on CTASI, median (range) | 5 (4–10) | 8 (0–10) | .051** |
| Pc-ASPECTS score on F/U image, median (range) | 1.5 (0–7) | 6 (0–10) | .015* |
Note:—NIHSS indicates National Institutes of Health Stroke Scale score; GCS, Glasgow Coma Scale score; CTA, CT angiography; IV, intravenous; IA, intra-arterial.
* Indicates results that are statistically significant.
** Indicates results with borderline statistical significance.