Table 2:

Comparison of DTI parameters between children with HCP and age-matched control subjects

ROI	DTI Parameter	n	HCP	Norm	Paired t test	df	P
gCC	FA	16	0.341 ± 0.101	0.525 ± 0.092	6.66	15	.002^*
	MD^†	16	1.724 ± 0.848	1.355 ± 0.398	2.66	15	.049^*
	Axial diffusivity^†	16	2.368 ± 1.100	2.201 ± 0.559	0.58	15	NS
	Radial diffusivity^†	16	1.406 ± 0.741	0.929 ± 0.341	4.08	15	.010^*
bCC	FA	7	0.270 ± 0.113	0.513 ± 0.088	4.20	6	.023^*
	MD^†	7	1.750 ± 0.634	1.334 ± 0.443	3.50	6	.043^*
	Axial diffusivity^†	7	2.206 ± 0.64	2.181 ± 0.681	0.135	6	NS
	Radial diffusivity^†	7	1.526 ± 0.647	0.907 ± 0.335	4.22	6	.028^*
sCC	FA	15	0.403 ± 0.164	0.564 ± 0.088	3.42	14	.027^*
	MD^†	15	1.722 ± 0.757	1.393 ± 0.454	1.92	14	NS
	Axial diffusivity^†	15	2.426 ± 0.876	2.383 ± 0.717	0.19	14	NS
	Radial diffusivity^†	15	1.373 ± 0.722	0.946 ± 0.408	2.62	14	.050^*
ALIC	FA	17	0.400 ± 0.112	0.402 ± 0.082	0.07	16	NS
	MD^†	17	1.099 ± 0.473	1.048 ± 0.367	0.64	16	NS
	Axial diffusivity^†	17	1.596 ± 0.586	1.531 ± 0.457	0.58	16	NS
	Radial diffusivity^†	17	0.854 ± 0.427	0.811 ± 0.331	0.60	16	NS
PLIC	FA	17	0.530 ± 0.123	0.501 ± 0.068	1.71	16	NS
	MD^†	17	1.060 ± 0.475	1.062 ± 0.312	0.02	16	NS
	Axial diffusivity^†	17	1.701 ± 0.628	1.697 ± 0.435	0.03	16	NS
	Radial diffusivity^†	17	0.741 ± 0.417	0.749 ± 0.266	0.12	16	NS

Note:—ROI indicates region of interest; df, degrees of freedom; gCC, genu of the corpus callosum; FA, fractional anisotropy; MD, mean diffusivity; bCC, body of the corpus callosum; sCC, splenium of the corpus callosum; ALIC, anterior limb of the internal capsule; PLIC, posterior limb of the internal capsule; NS, not significant.
* P value is adjusted for multiple testing with the false discovery rate method.
† The units of MD, axial diffusivity, and radial diffusivity are all in 10 ⁻³mm²/s.