Comparison of clinical outcomes in IV-only versus IV-plus-intervention groups*
| Variable | IV + Intervention | IV Only | P | Effect Size† |
|---|---|---|---|---|
| No. patients | 33 | 30 | ||
| Admission NIHSS score‡ (mean ± SD) | 15.8 ± 3.5 | 16.0 ± 3.5 | ||
| Admission NIHSS score (median, 25%, 75%) | 15 (13, 19) | 16.5 (14, 18.75) | .822 | 0.033 |
| Follow-up NIHSS score | 8 (2, 14) | 14 (11.5, 7) | .037 | 0.535 |
| NIHSS score improvement | 9 (2, 12) | 12 (3.5, −22) | .025 | 0.575 |
| Significance of change from admission | P = .071 | P = .173 | ||
| ≥4 NIHSS points | 22 (66.7) | 15 (50%) | .208 | 2.00 (0.72–5.53) |
| ≥10 NIHSS points | 16 (48.5%) | 7 (23.3%) | .066 | 3.09 (1.04–9.17) |
| Favorable outcome (NIHSS scores, 0–2) | 11 (33.3%) | 4 (13.3%) | .080 | 3.25 (0.91–11.66) |
| 90-Day mortality | 4 (12.1%) | 12 (40.0%) | .019 | 0.21 (0.06–0.74) |
Note:—NIHSS indicates National Institutes Health Stroke Scale.
* Follow-up assessment performed at day 7 or discharge for the intervention group and discharge or follow-up visit for the control group (see text).
† Effect size measured as Cohen D for continuous variables or odds ratio (95% CI) for categoric variables.
‡ Admission NIHSS scores for all patients ≥10.