Age-related white matter change scale*
| Location | Characteristics† |
|---|---|
| White matter | |
| 0 | No lesions (including caps/bands) |
| 1 | Focal lesions |
| 2 | Beginning confluence of lesions |
| 3 | Diffuse involvement of the entire region, irrespective of U fiber involvement |
| Basal ganglia | |
| 0 | No lesions |
| 1 | 1 focal lesion (≥5 mm) |
| 2 | >1 focal lesion |
| 3 | Confluent lesions |
* Brain regions assessed included frontal, parieto-occipital, temporal, infratentorial/cerebellum, and basal ganglia (striatum, globus pallidus, thalamus, internal/external capsule, and insula).
† White matter changes on MR imaging are defined as bright lesions ≥5 mm on T2, proton-density, or fluid-attenuated inversion recovery images. Lesions on CT were defined as hypodense areas of ≥5 mm; left and right hemispheres were rated separately.