Metabolite concentrations in cerebral white matter of 7 patients with X-ALD and 14 controls (in vivo)
| Center of Lesion (mean) | Edge of Lesion (mean) | NAWM (mean) | Controls (mean) | |
|---|---|---|---|---|
| MTR (%) | 11.5 ± 3.3a | 23.0 ± 1.5a | 29.0 ± 2.5 | 31.8 ± 1.5 |
| ADC (10−3 mm2/s) | 2.1 ± 0.4a | 1.2 ± 0.5a | 0.83 ± 0.05 | 0.81 ± 0.07 |
| FA | 0.20 ± 0.04a | 0.30 ± 0.05a | 0.43 ± 0.02 | 0.37 ± 0.04a |
| tCr (mmol/L) | 2.7 ± 0.9a | 4.3 ± 0.5 | 4.8 ± 1.0 | 4.5 ± 0.6 |
| tNAA (mmol/L) | 1.9 ± 1.8a | 4.9 ± 1.9a | 7.2 ± 0.9 | 7.7 ± 1.0 |
| Cho (mmol/L) | 1.4 ± 0.9 | 1.9 ± 0.3b | 1.5 ± 0.4 | 1.3 ± 0.2 |
| mIns (mmol/L) | 5.0 ± 1.5a | 4.8 ± 0.6a | 4.2 ± 1.1 | 3.6 ± 0.3 |
| Lac (mmol/L) | 1.8 ± 2.0a | 2.3 ± 2.5b | 0.5 ± 0.6 | 0.2 ± 0.3 |
a Significantly different from NAWM (P< .01).
b Significantly different from NAWM and center of lesion (P< .01).