Specificity in the unblinded evaluation
Dose Group and Postdose Time Point | Total Lymph Nodes | Sequence Specificity (%) | ||
---|---|---|---|---|
T2-Weighted | FFE-25 | FFE-80 | ||
1.1 mg Fe/kg | ||||
6 h | 41 | 78 | 12 | 20 |
12 h | 41 | 90 | 56* | 74* |
24 h | 41 | 80 | 62* | 87* |
36 h | 41 | 56 | 62* | 65† |
1.7 mg Fe/kg | ||||
6 h | 25 | 88 | 32 | 44 |
12 h | 25 | 92 | 64 | 84 |
24 h | 25 | 100 | 72 | 84 |
36 h | 25 | 92 | 84 | 76 |
2.6 mg Fe/kg | ||||
6 h | 25 | 92 | 56 | 68 |
12 h | 25 | 96 | 84 | 96 |
24 h | 25 | 100 | 96 | 100 |
36 h | 25 | 100 | 96 | 92 |
3.4 mg Fe/kg | ||||
6 h | 19 | 95 | 63 | 89 |
12 h | 19 | 100 | 83‡ | 95 |
24 h | 19 | 89 | 84 | 95 |
36 h | 19 | 79 | 79 | 79 |
Note.—The specificity was based on the signal intensity and lymph node architecture. A decrease in the signal intensity of a heterogeneous lymph node indicated a false-positive result.
* The total number of lymph nodes was 39.
† The total number of lymph nodes was 40.
‡ The total number of lymph nodes was 18.