TABLE 1:

Clinical characteristics of patients with perineural spread of malignant melanoma

Patient no.	Age (years)/Sex	Risk Factors	Original Presenting Lesion	Time to Develop Clinical Neuropathy	Pathology	Delay in Diagnosis of Perineural Disease	Cranial Neuropathies	Biopsy	Years of Follow-Up	Outcome
1	59/M	Lentigo maligna	Mass on lower lip	11 years	Mucosal	13 months	V2, V3, VII	Mandibular nerve	4	AWD
2	29/M	None known	Mass on lower lip	3 years	Desmoplastic	1 month	V3	Inferior alveolar nerve	5	AWD
3	78/M	Lentigo maligna	Pigmented lesion over left forehead	1.5 years	Desmoplastic	10 months	III, IV, V1, VI, VII	Supraorbital nerve, CT-FNA	2	DOD
4	41/F	None	Right nasopharyngeal mass	3 years	Mucosal	N/A	V1, V2, VI, VII	Infraorbital nerve	1 month	Unknown
5	70/F	Family history of melanoma	Mass over right nose	2.5 years	Desmoplastic	6 months	III, IV, V, VI, VII, VIII, IX, X, XI, XII	Infraorbital nerve, CT-FNA	5	DOD
6	49/F	None	Mass on upper lip	3 years	Desmoplastic	1 month	V2	Infraorbital nerve	1	AWD
7	70/F	Lentigo maligna	Left supraorbital skin mass	12 years	Spindle-cell	11 months	III, V1, VI	Supraorbital nerve	2	DOD
8	64/M	None	Left infraorbital skin mass	3 years	Desmoplastic	8 months	V1, V2	Infraorbital nerve	2	DOD