Univariate correlations between MR imaging measures of MS burden of disease and clinical disability
| Measure | EDSS Score, All Patients (n = 239) | EDSS Score, Placebo Group (n = 120) | EDSS Score, GA Group (n = 119) | |||
|---|---|---|---|---|---|---|
| Baseline | Change | Baseline | Change | Baseline | Change | |
| Baseline T2 LV | 0.28 (<.001) | 0.16 (.02) | 0.27 (.003) | 0.09 | 0.29 (.001) | 0.24 (.008) |
| Baseline T1 LV | 0.19 (.003) | 0.18 (.006) | 0.24 (.009) | 0.12 | 0.12 | 0.23 (.01) |
| T2 DLV | 0.13 | 0.17 (.007) | 0.12 | 0.10 | 0.10 | 0.25 (.005) |
| T1 DLV | 0.17 (.007) | 0.18 (.006) | 0.16 | 0.09 | 0.20 (.03) | 0.31 (<.001) |
Note.—Values are the Spearman rank correlation coefficients. Data in parentheses are P values ≤.05. DLV indicates the difference in lesion volume between month 9 images and baseline images; EDSS change, the difference in the EDSS score between month 9 evaluations and baseline evaluations; and LV, lesion volume.