Main MR imaging signal changes and correspondent metabolic profile of MR spectroscopy during the evolution of the disease

Months after OnsetMR ImagingCho/CrNAA/CrLactateLipids
1T2 hyperintensity of the entire corpus callosum; foci of in the centrum semiovale1.351.98++
4Persistent hyperintensity in the splenium and posterior half of the body of the corpus callosum; corpus callosum slightly atrophic1.061.26+
11Slight hyperintensity of the splenium; moderate atrophy of the corpus callosum0.871.45
Normal range0.9–1.31.8–2.4
  • Note.—Cho indicates choline; Cr, creatine; NAA, N-acetylaspartate.