Table 2:

Means, number of subjects from whom the data was derived (in parentheses), and P values (from unequal variance t tests) of the absolute NAA, Cr, Cho, and mIns hippocampal GM concentrations and the volumes of the bilateral hippocampi in controls and patientsa

MetaboliteControlsPatientsP Value
NAA (mM)8.7 ± 1.2 (n = 11)8.8 ± 1.6 (n = 16).876
Cr (mM)7.4 ± 1.2 (n = 10)b8.7 ± 2.2 (n = 19)b.035b
Cho (mM)2.1 ± 0.3 (n = 10)2.3 ± 0.7 (n = 18).189
mIns (mM)5.2 ± 0.9 (n = 10)6.1 ± 1.5 (n = 12).161
Volume (cm3)8.4 ± 0.5 (n = 11)b7.5 ± 0.9 (n = 19)b.003b
  • a Note the elevation of Cr and the reduction in volume in patients compared with controls.

  • b Significant difference.