Table 3:

Regions of increased MD in patients with ALS compared with HCs accounting for gray and white matter volume loss

Cluster Size^{^a}	BA	Regions	MNI Coordinates (mm)			T Values
Cluster Size^{^a}	BA	Regions	X	Y	Z	T Values
59	BA6	L precentral gyrus	−54	1	26	5.29
64	BA6	R precentral gyrus	49	2	25	5.13
224		R putamen	21	17	−4	4.71
		R middle orbitofrontal white matter	17	18	−10	3.45
127		L superior orbitofrontal white matter	−18	32	−8	4.46
33	BA45	L inferior frontal gyrus	−45	9	24	4.34
88		R middle occipital white matter	38	−73	6	4.34
78		R posterior limb of the internal capsule	16	−14	0	4.13
47	BA21	L middle temporal gyrus	−59	−60	1	4.10
28	BA39	R angular gyrus	40	−54	40	4.07
24	BA20	R inferior temporal pole	65	−13	−23	4.06
41	BA3	L postcentral gyrus	−60	−11	31	4.02
23	BA21	R middle temporal pole	51	12	−31	4.01
116		R genu of the corpus callosum	9	32	−1	3.98
		R superior orbitofrontal white matter	17	38	−4	3.63
108		L anterior lobe of the cerebellum	−18	−25	−29	3.95
		L middle cerebellar peduncle	−13	−32	−29	3.90
20	BA22	R superior temporal lobe	52	−46	22	3.91
38	BA13	L insula	−38	14	−1	3.90
55	BA45	L inferior frontal gyrus	−37	43	11	3.76
23		R anterior lobe of the cerebellum	16	−55	−25	3.68
26	BA40	L supramarginal gyrus	−49	−24	32	3.58
	BA40	L supramarginal gyrus	−40	−24	33	3.46

a The number of voxels. P < .001 uncorrected within at least 20 contiguous voxels.