Tumor perfusion parameters by LRC status, before, during, and after RTa
| Parameter | Locoregional Status | Baseline Prior to RT, LRF (n = 2); LRC (n = 13) | During RT (SD) | 6 Weeks Post-RT, LRF (n = 2); LRC (n = 10) | ||
|---|---|---|---|---|---|---|
| Week 2, LRF (n = 2); LRC (n = 13) | Week 4, LRF (n = 2); LRC (n = 12) | Week 6, LRF (n = 1); LRC (n = 10) | ||||
| BF (mL/100 g/min) | LRF | 53.4 (1.8) | 43.9 (9.9) | 217.7 (243.8) | 16.2 (NA) | 28.4 (20.8) |
| LRC | 118.0 (66.1) | 135.8 (71.5) | 91.6 (51.9) | 137.8 (149.0) | 71.5 (56.6) | |
| P value | .004 | .0008 | .598 | NA | .122 | |
| BV (ml/100 g) | LRF | 4.5 (1.9) | 3.6 (1.1) | 6.7 (6.2) | 2.3 (NA) | 3.2 (3.1) |
| LRC | 5.6 (2.0) | 6.1 (2.5) | 4.6 (2.2) | 6.2 (4.9) | 4.0 (2.8) | |
| P value | .546 | .081 | .721 | NA | .766 | |
| MTT (s) | LRF | 6.4 (2.0) | 7.2 (2.8) | 3.5 (1.8) | 11.1 (NA) | 7.8 (2.2) |
| LRC | 4.9 (2.6) | 4.4 (2.2) | 5.1 (4.7) | 4.2 (1.3) | 5.7 (2.5) | |
| P value | .461 | .379 | .438 | NA | .381 | |
| CP (mL/100 g/min) | LRF | 7.7 (2.3) | 6.6 (5.6) | 29.5 (28.5) | 4.4 (NA) | 9.9 (9.2) |
| LRC | 16.6 (9.3) | 22.0 (7.5) | 19.0 (11.1) | 11.3 (8.1) | 15.6 (8.9) | |
| P value | .02 | .098 | .694 | NA | .537 | |
a Data are presented as a mean ± SD. P values are calculated from an independent samples t test comparing mean CTP parameter values in the LRC versus LRF groups. CTP parameters were not measured at week 6 in 1 of the 2 patients with LRF; these are indicated by NA.