Table 1:

Baseline characteristics

Group 1 Fam + HCI +				Group 3 Matches Group 1			Group 2 Fam + HCI −				Group 4 Matches Group 2
	Sex	Age	Pedigree		Sex	Age		Sex	Age	Pedigree		Sex	Age
1	M	9	IV.2	1	F	7	1	F	3	IV.1^#	1	F	3
2	F	10	IV.14	2	M	9	2	M	4	IV.15^*	2	M	5
3	F	13	IV.12	3	F	11	3	F	4	IV.6^#	3	M	5
4	F	22	IV.11	4	F	20	4	M	5	IV.5^#	4	F	6
5	F	36	III.3	5	M	31	5	M	7	IV.4^#	5	M	9
6	M	39	III.8	6	M	39	6	M	14	IV.13^#	6	M	12
7	F	42	III.2	7	F	39	7	F	22	IV.10	7	F	20
8	F	44	III.7	8	F	42	8	F	23	IV.9	8	F	24
9	F	45	III.6	9	F	43	9	M	25	IV.8	9	M	28
10	M	68	II.2	10	M	67	10	M	38	III.2	10	M	30
							11	M	40	III.5	11	M	45
							12	M	42	III.4
Mean age		33		Mean age		31	Mean age (without IV.15)		20		Mean age		17

Note:—M indicates male; F, female; age, age of scan;
↵* , excluded, diagnosis uncertain;
↵# , unaffected according to genetic linkage analysis (unpublished data); Fam, family member.