Pathway analysis of proteins up-regulated in the dome of densely packed aneurysms compared with loosely packed aneurysms at 2 weeks following coil embolization
| Biologic Pathways | Number of Proteins Up-Regulated | Protein Symbol |
|---|---|---|
| Gap junction | 7 | GNAI1, GNAI2, GNAI3, GNAQ, GNAS, PRKACA, MAPK1 |
| Citrate cycle | 6 | IDH3B, IDH1, MDH2, PDHA1, SUCLG1, SUCLG2 |
| Vascular smooth muscle contraction | 6 | GNA13, GNAQ, GNAS, PRKACA, MAPK1, PPP1CA |
| Lysosome | 6 | CTSC, CTSD, CTSK, CD63, M6PR, PPT1 |
| Tight junction | 6 | EPB41, ACTG1, GNAI1, GNAI2, GNAI3, PPP2CA |
| Fatty acid metabolism | 5 | ACADL, ACADM, ACAA1, ACAT1, ACAA2 |
| Valine, leucine, and isoleucine degradation | 5 | ACADM, IVD, ACAA1, ACAT1, ACAA2 |
Note:—Top 10 biologic process with descending protein count and EASE score, P < 0.05.