Literature overview of important recent studies on aneurysm rerupture of embolized ruptured cerebral aneurysms
| Patients | Aneurysm Occlusion Raymond Classes (%) 1–3 (<70%) | Reruptured | ||||
|---|---|---|---|---|---|---|
| No. | FU (mo) | Overall (%) | Raymond Classes (%) 1–3 (<70%) | |||
| Johnston et al, 2008 (CARAT)3 | 1001 | 48 | 75.9/17.3/5.1/(1.7) | 1.9 (n = 19) | 1.1/2.9/5.9/(17.6) | S |
| Molyneux et al, 2005, 2009 (ISAT) (late rebleeding)1,2 | 1096 (881)a | 60 | 66/26/8 (11% without DSA) | 1.1 (n = 10) | 0.5/1.7/4.3 | NDa |
| Jartti et al, 2010 (early rebleeding)13 | 194 | 1 | 31.5/51/27.5 | 3.6 (n = 7) | [2.5]/8.8 | NSb |
| Sluzewski et al, 2005 (late rebleeding)15 | 393 | 47.7 | [93.2]/6.8b | 1.1 (n = 4) | [0.8]/7.4 | Sb |
| Sluzweski and van Rooij, 2005 (early rebleeding)16 | 431 | 1 | ND | 1.4 (n = 6) | ND | Sc |
| Plowman et al, 2010 (late rebleeding)17 | 570 | 73.7 | 62.5/32.1/5.6 | 1.1 (n = 6) | 0.9/4.6/0 | NS |
| Renowden et al, 200918 | 711 | 17 | 62.5/33/5.0 | 1.7 (n = 12) | [1.5]/2.7 | NDb |
| Willinsky et al, 200919 | 377 | 22.3 | 43/36/20 | 2.1 (n = 8) | 1.1/2.8/2.5 | NS |
| Kang et al, 201020 | 797 | ND | 74.2/[25.8]d | 1.0 (n = 8) | 1.0/[1.0] | NDd |
| Piotin et al, 200922 | 74 | 14 | 50.9/23/26.1 | 1.3 (n = 1) | ND | ND |
| Choi et al, 201021 | 91 | 34.4 | 100/0/0 | 0 | 0 | ND |
| Sherif and Plenk, 20117 | 249 | 59 | SOR, 28.1/59.8/11.1; | 2.8% (n = 7) | SOR, 0/3.4/7.3 | NS |
| COR, 6.5/49.9/41.4/(2.1) | COR, 0/0.7/5.2/(16.7) | S | ||||
Note:—FU indicates follow-up time, for all citations: only rebleeding of treated aneurysms; S, significant; NS, not significant; ND, no data available; ISAT, International Subarachnoid Aneurysm Trial.
↵a Patients with angiograms, rebleedings related to patients with available angiograms (data provided by Dr Molyneux).
↵b Raymond Class 1 + 2 pooled.
↵c In univariate logistic regression.
↵d Class 2 + 3 pooled.