Volumetric gray matter differences in patients with clinically isolated syndrome with low- and high-T2 lesion volumea
| CIS with T2-LV < 4.49 mL (n = 106) (mean) (SD)b | CIS with T2-LV > 4.49 mL (n = 106) (mean) (SD)b | % Difference | SED | P Value | |
|---|---|---|---|---|---|
| NBV | 1499 (67.1) | 1487 (80.1) | −0.8 | 6.5 | .238 |
| NLVV | 35.3 (9.8) | 40.3 (12.4) | +14.2 | 0.5 | .001 |
| NCV | 618.18 (30.7) | 610.31 (35.1) | −1.27 | 4.53 | .084 |
| Total SDGM | 64.52 (3.65) | 61.96 (3.79) | −3.97 | 0.51 | <.0001 |
| Caudate | 9.6 (0.91) | 9.05 (1.01) | −5.73 | 0.13 | <.0001 |
| Putamen | 13.46 (0.94) | 13.10 (1.1) | −2.67 | 0.14 | .010 |
| Globus pallidus | 4.8 (0.37) | 4.68 (0.34) | −2.50 | 0.04 | .007 |
| Thalamus | 21.73 (1.36) | 20.77 (1.47) | −4.42 | 0.19 | <.0001 |
| Hippocampus | 10.01 (0.97) | 9.64 (0.87) | −3.70 | 0.13 | .004 |
| Amygdala | 3.59 (0.41) | 3.45 (0.46) | −3.90 | 0.06 | .021 |
| Nucleus accumbens | 1.32 (0.22) | 1.28 (0.26) | −3.03 | 0.04 | .204 |
Note:—SDGMV indicates subcortical deep gray matter volume; SED, standard error of difference; LV, lesion volume.
↵a All volumes are reported in milliliters.
↵b Student t test was used to assess volumetric differences between patients with CIS with T2 lesion volume <4.49 mL and those with CIS with >4.49 mL T2 lesion volume.