Table 1:

Clinical and radiologic characteristics of patients with SPMS

ParameteraImpaired n = 18Nonimpaired n = 19P value
Age (years)58 ± 1055 ± 60.32
Gender (F/M)12/611/80.73
Education level (years; median [IQR])15.5 (13–17.5)16 (13–17.5)0.99
Disease duration (years; median [IQR])23 ± 1217 ± 60.08
BDI (score; median [IQR])9 (7.25–10)5.5 (5–10.25)0.21
EDSS (score; median [IQR])6.5 (6.13–6.5)6 (6–6.5)0.29
GM qCBF (ml/100 g/min)57 ± 1760 ± 180.003b
WM qCBF (ml/100 g/min)38.4 ± 15.440.3 ± 18.50.04b
GM qCBV (ml/100 g)3.8 ± 1.14.1 ± 1.40.0001b
WM qCBV (ml/100 g)2.6 ± 0.62.9 ± 0.90.004b
GM MTT (seconds)4.11 ± 0.754.18 ± 0.760.18
WM MTT (seconds)4.43 ± 0.844.46 ± 0.790.63
WML volume0.02 ± 0.010.009 ± 0.0090.02b
Brain parenchymal fraction0.79 ± 0.030.82 ± 0.030.01b
CSF fraction0.17 ± 0.040.15 ± 0.030.04b
GM fraction0.43 ± 0.010.45 ± 0.030.09
WM fraction0.36 ± 0.020.38 ± 0.030.09
rR0.11 ± 0.010.11 ± 0.020.50
WM T1670.32 ± 25.38600.02 ± 20.520.12
WCF1.31 ± 0.581.26 ± 0.410.83

  • Note:—BDI indicates Beck Depression Inventory; EDSS, Expanded Disability Status Scale; IQR, interquartile range; rR, relative recirculation, WCF, water correction factor; WML, white matter lesion.

  • ↵a Value is mean ± standard deviation unless otherwise stated.

  • ↵b Significant result (P < .05).