Frequency and characteristics of brain MRI abnormalities seen in children with ret+ versus ret− CM

Characteristics	Ret− (n = 32)	Ret+ (n = 120)	Fisher P Value	OR (95% CI)
Age (mean in months)	55.1 (27.9)	48.6 (27.6)	.23	–
Sex (% male)	40.6	54.2	–	1.72 (0.78–3.81)
Increased cerebral volume ≥4	7^*	57^*	.01^*	3.23 (1.30–8.04)^*
White matter T2 abnormalities	13^*	86^*	<.005^*	3.7 (1.6–8.3)^*
White matter DWI abnormalities	11	54	.32	1.6 (0.7–3.5)
T2 cortical abnormalities	9^*	74^*	.001^*	4.1 (1.7–9.7)^*
Cortical DWI abnormalities	5	25	.62	1.4 (0.5–4.1)
Pontine T2 changes	9	57	.07	2.3 (0.9–5.4)
T2 changes	15^*	89^*	.005^*	3.3 (1.5–7.3)^*
Basal ganglia involvement	12^*	101^*	<.00001^*	8.9 (3.7–21.1)^*
Basal ganglia DWI abnormalities	4^*	48^*	<.01^*	4.7 (1.5–14.2)^*
Thalamic involvement	10^*	77^*	.001^*	3.9 (1.7–9.1)^*
Corpus callosum T2 abnormalities	6^*	59^*	<.005^*	4.2 (1.6–10.9)^*
Corpus callosum DWI abnormalities	6^*	52^*	<.05^*	3.3 (1.3–8.6)^*
Splenium predominance	5	38	.08	2.5 (0.9–7.0)
Posterior fossa DWI abnormalities	0^*	6^*	.34^*	Undefined
Posterior fossa signal abnormalities	7^*	59^*	<.01^*	3.5 (1.4–8.6)^*
Pre-existing abnormality	5	14	.76	0.7 (0.2–2.2)