Correlations of the change in MD or FA with the change in clinical scores between times T0 (pre-HSCT) to T4 (1 year after HSCT)
| Region | ΔVIQ (T0–T4) | ΔPIQ (T0–T4) | ΔAF (T0–T4) | ΔNFS (T0–T4) | ||||
|---|---|---|---|---|---|---|---|---|
| ΔMD | ΔFA | ΔMD | ΔFA | ΔMD | ΔFA | ΔMD | ΔFA | |
| ATWM | −0.647 (.448) | 0.257 (.872) | 0.092 (.893) | 0.036 (.939) | −0.473 (.508) | 0.143 (.908) | 0.654 (.359) | −0.317 (.973) |
| BIC | −0.771 (.266) | 0.200 (.872) | −0.324 (.871) | −0.577 (.637) | −0.679 (.409) | 0.143 (.908) | 0.049 (.960) | −0.171 (.973) |
| BoCC | −0.771 (.266) | 0.371 (.808) | −0.342 (.871) | 0.685 (.527) | −0.643 (.409) | 0.393 (.728) | 0.537 (.359) | −0.687 (.228) |
| CST-pons | −0.464 (.611) | 0.086 (.872) | 0.091 (.893) | 0.072 (.939) | −0.468 (.508) | 0.107 (.908) | 0.491 (.412) | −0.220 (.973) |
| CWM | −0.754 (.266) | 0.486 (.695) | −0.527 (.553) | 0.054 (.939) | −0.631 (.409) | 0.357 (.746) | 0.333 (.665) | −0.195 (.973) |
| DSCP | −0.580 (.481) | 0.543 (.632) | −0.645 (.553) | 0.487 (.637) | −0.505 (.508) | 0.714 (.450) | 0.247 (.760) | −0.464 (.670) |
| GeCC | 0.143 (.880) | −0.334 (.820) | 0.645 (.553) | −0.654 (.527) | 0.162 (.865) | −0.259 (.861) | −0.575 (.359) | 0.125 (.973) |
| LGN | −0.600 (.481) | −0.086 (.872) | 0.216 (.893) | −0.036 (.939) | −0.464 (.508) | −0.250 (.861) | 0.220 (.761) | 0.146 (.973) |
| LL | 0.058 (.957) | 0.551 (.632) | 0.573 (.553) | −0.218 (.939) | 0.126 (.865) | 0.487 (.566) | −0.565 (.359) | 0.025 (1.000) |
| MeyLo | −0.257 (.789) | −0.086 (.872) | 0.306 (.871) | −0.100 (.939) | −0.107 (.865) | −0.054 (.908) | 0.000 (1.000) | 0.184 (.973) |
| MGN | −0.203 (.831) | −0.600 (.632) | 0.187 (.893) | −0.216 (.939) | −0.074 (.875) | −0.643 (.452) | −0.100 (.910) | 0.732 (.228) |
| ML | −0.886 (.120) | −0.174 (.872) | 0.126 (.893) | 0.500 (.637) | −0.679 (.409) | −0.072 (.908) | 0.614 (.359) | 0.000 (1.000) |
| NAFWM | −0.928 (.076) | 0.771 (.632) | −0.218 (.893) | −0.300 (.939) | −0.703 (.409) | 0.721 (.450) | 0.123 (.910) | −0.061 (1.000) |
| OR | −0.371 (.684) | 0.771 (.632) | −0.649 (.553) | 0.721 (.527) | −0.429 (.534) | 0.786 (.450) | 0.903 (.038)a | −0.854 (.105) |
| OT | −0.371 (.684) | 0.543 (.632) | −0.518 (.553) | −0.090 (.939) | −0.324 (.699) | 0.536 (.566) | 0.344 (.665) | −0.712 (.228) |
| PLIC | −0.493 (.610) | 0.543 (.632) | −0.873 (.190) | 0.721 (.527) | −0.505 (.508) | 0.536 (.566) | 0.663 (.359) | −0.830 (.105) |
| POWM | −0.257 (.789) | 0.143 (.872) | 0.126 (.893) | −0.541 (.637) | −0.250 (.799) | 0.071 (.908) | 0.244 (.760) | 0.171 (.973) |
| SpCC | 0.029 (.957) | 0.714 (.632) | 0.523 (.553) | −0.360 (.901) | 0.143 (.865) | 0.643 (.452) | −0.537 (.359) | 0.000 (1.000) |
| TB | −0.943 (.076) | 0.429 (.754) | −0.036 (.939) | −0.108 (.939) | −0.929 (.057) | 0.500 (.566) | 0.687 (.359) | −0.488 (.670) |
Note:—Values are for Spearman correlation; values in parentheses are P values (adjusted for multiple comparisons). AF indicates adaptive functioning; ATWM, anterior temporal WM; BIC, brachium of the inferior colliculus; BoCC, body of the corpus callosum; CST, corticospinal tract; CWM, cerebral WM; DSCP, decussation of the superior cerebellar peduncles; GeCC, genu of the corpus callosum; LL/ML, lateral/medial lemnisci; LGN/MGN, lateral/medial geniculate nuclei; MeyLo, Meyer loop; NAFWM, normal-appearing frontal WM; OR, optic radiations; OT, optic tracts; PIQ, perceptual/visual-motor reasoning IQ; PLIC, posterior limb of the internal capsule; POWN, parieto-occipital WM; SpCC, splenium of the corpus callosum; TB, trapezoid body; VIQ, verbal IQ.
↵a p < 0.05.