Association between measures of WMH and cognitive function using MoCA cutoffs for cognitive deficit as originally published and as established in our cohort
| Normal (MoCA>25) | Deficit (MoCA≤25) | P Value | Normal (MoCA>19) | Deficit (MoCA≤19) | P Value | |
|---|---|---|---|---|---|---|
| N (%) | 210 (41.2) | 300 (58.8) | 441 (86.5) | 69 (13.5) | ||
| Visual Scalea | ||||||
| Absent (%) | 103 | 117 | 0.050 | 199 | 21 | 0.001 |
| Minimal (%) | 92 | 143 | 204 | 31 | ||
| Moderate (%) | 12 | 30 | 29 | 13 | ||
| Advanced (%) | 3 | 10 | 9 | 4 | ||
| Automated Volumeb (mL), median (range) | 0.815 (0.14–39.64) | 0.95 (0.13–83.18) | 0.014 | 0.90 (0.13–83.18) | 1.05 (0.14–45.48) | 0.091 |