Evolution of tissue-specific subcortical deep gray matter structures during 5 years, split by progression status at 5 yearsa
| Sustained Disease Progression (mean) (SD) (median) | Stable Disease (mean) (SD) (median) | P Value | |
|---|---|---|---|
| Total SDGMV (No. patients) | 81 | 78 | |
| Absolute change | −2.5 (1.6) −2.5 | −2 (1.1) −1.9 | |
| % Change | −5.7 (3.8) −5.3 | −4.4 (2.5) −4 | .03 |
| SDGMV structures | |||
| Caudate nucleus (No. patients) | 80 | 79 | |
| Absolute change | −0.4 (0.4) −0.3 | −0.3 (0.3) −0.3 | |
| % Change | −5.9 (7) −5.1 | −4.5 (4.6) −4.5 | .3 |
| Putamen (No. patients) | 80 | 79 | |
| Absolute change | −0.5 (0.4) −0.5 | −0.4 (0.4) − 0.5 | |
| % Change | −5.8 (4.2) −5.7 | −4.3 (3.7) −4.5 | .02 |
| Globus pallidus (No. patients) | 80 | 79 | |
| Absolute change | −0.06 (0.02) −0.07 | −0.02 (0.02) −0.02 | |
| % Change | −1.8 (5.1) −2.1 | −0.5 (4.5) −0.7 | .99 |
| Thalamus (No. patients) | 80 | 79 | |
| Absolute change | −0.9 (0.6) −0.8 | −0.7 (0.5) −0.6 | |
| % Change | −6.2 (4.4) −5.5 | −4.5 (3.2) −3.9 | .01 |
| Hippocampus (No. patients) | 80 | 79 | |
| Absolute change | −0.4 (0.4) −0.4 | −0.4 (0.4) −0.4 | |
| % Change | −5.5 (5.5) −5.7 | −5.6 (5.6) −4.8 | .9 |
| Nucleus accumbens (No. patients) | 80 | 79 | |
| Absolute change | −0.08 (0.1) −0.08 | −0.09 (0.1) −0.1 | |
| % Change | −7.6 (14.8) −9.1 | −8.7 (11.8) −10 | .1 |
| Amygdala (No. patients) | 80 | 79 | |
| Absolute change | −0.1 (0.2) −0.2 | −0.1 (0.3) −0.2 | |
| % Change | −5.1 (8.3) −6.2 | −4.6 (9.7) −5.8 | .95 |
Note:—SDGMV indicates subcortical deep gray matter volume.
↵a The difference between the groups was calculated using regression analysis adjusting for age, disease duration, and change of treatment status during the 5-year follow-up. The absolute volume changes are presented in milliliters. Variables with skewed distributions (% change in globus pallidus and % change in amygdala) were transformed using Box-Cox transformations.