Table 1:

Definition of response criteria for unidimensional (RECIST), bidimensional (Macdonald), and volumetric techniques

CriteriaCRPRSDPD
RECISTResolution of all enhancement≥30% Decrease in sum of max dimensionsAll others≥20% Increase in sum of max dimensions
MacdonaldResolution of all enhancement≥50% Decrease in product of 2 orthogonal dimensionsAll others≥25% Increase in product of 2 orthogonal dimensions
VolumetricResolution of all enhancement≥65% Decrease in volumeAll others≥40% Increase in volume

  • Note:—CR indicates complete response; PR, partial response; SD, stable disease; PD, progression of disease; RECIST, Response Evaluation Criteria in Solid Tumors; max, maximal.