Demographic and clinical characteristics for patients with HSP and the control groupa
| Patients with HSP (n = 12) | Healthy Controls (n = 12) | P Value | |
|---|---|---|---|
| Age at MRI (yr) | 50 (49 ± 8) | 48 (48 ± 5) | .5b |
| Sex (female) | 50% | 67% | .4c |
| Disease duration (yr) | 23 (24 ± 16) | – | – |
| Disease onset (yr) | 23 (25 ± 18) | – | – |
| Spastic gate loci | |||
| SPG10 | 8% (1) | ||
| SPG3a | 8% (1) | ||
| SPG4 | 58% (7) | ||
| SPG7+SPG4 | 8% (1) | ||
| SPG5 | 17% (2) |