Characteristic | ON | Controlsa | P Valueb | ON-MS | Isolated ON | P Valuec |
---|---|---|---|---|---|---|
No. of patients | 21 | 21 | 11 | 10 | ||
Age (mean) (SD) (yr) | 30.3, 10.7 | 34.2, 8.7 | NS | 26.9, 9.5 | 34.0, 11.1 | NS |
Time to US examination: (median) (IQR) (days) | 5, 3–7 | 7, 3–10 | 4, 3–7 | NS | ||
BMI (mean) (SD) (Kg/m2) | 24.6, 4.8 | 23.6, 4.1 | NS | |||
Optic nerve sheath diameter (mm)d | ||||||
Affected eye (median) (IQR) | 6.3, 5.9–7.2 | 5.2, 4.8–5.5 | <.0001 | 6.2, 5.8–7.8 | 6.3, 5.9–7.0 | NS |
Fellow eye (median) (IQR) | 5.5, 5.1–6.2 | NS | 5.5, 5.0–6.2 | 5.6, 5.1–6.4 | NS | |
Optic nerve diameter (mm)e | ||||||
Affected eye (median) (IQR) | 3.0, 2.8–3.2 | 2.7, 2.5–2.8 | .001 | 2.9, 2.8–3.0 | 3.1, 2.8–3.2 | NS |
Fellow eye (median) (IQR) | 2.9, 2.8–3.1 | .009 | 2.9, 2.7–2.9 | 3.0, 2.8–3.2 | NS | |
VEP amplitude (μV) | ||||||
Affected eye (median) (IQR) | 5.2, 2.2–12.2 | 7.1, 2.2–12.2 | 4.0, 2.6–9.3 | NS | ||
Fellow eye (median) (IQR) | 8.4, 3.2–11.5 | 4.5, 2.8–8.7 | 11.1, 9.1–15.1 | NS | ||
VEP latency (ms) | ||||||
Affected eye (median) (IQR) | 124, 115–139 | 119, 115–128 | 134, 119–142 | NS | ||
Fellow eye (median) (IQR) | 107, 103–114 | 104, 103–114 | 108, 106–113 | NS |
Note:—IQR indicates interquartile range; ON-MS, optic neuritis in patients with prior relapses of multiple sclerosis; US, ultrasound; BMI, body mass index; NS, not significant.
↵a The average value between the right and left eye was used as a measure of OND and ONSD in healthy controls.
↵b Level of significance at .01, according to the Bonferroni correction for multiple comparisons.
↵c Level of significance at .006, according to the Bonferroni correction for multiple comparisons.
↵d The comparison of the affected and fellow eye was significant (P < .0001) in all ON, ON-MS, and isolated ON.
↵e The comparison of the affected and fellow eye was not significant in all ON, ON-MS, and isolated ON.