Common Terminology Criteria for Adverse Events, Version 4.0: central nervous system necrosisa
| Grade | Criteria |
|---|---|
| 1 | Asymptomatic; clinical, or diagnostic observations only; intervention not indicated |
| 2 | Moderate symptoms; corticosteroids indicated |
| 3 | Severe symptoms; medical intervention indicated |
| 4 | Life-threatening consequences; urgent intervention indicated |
| 5 | Death |
↵a Adapted from Department of Health and Human Services.15