Table 2:

Relationship between MRI lesions at baseline and evolution of MRI brain volumetric measures in patients with CIS over a 48-month period^{^a}

MRI Lesions at Baseline	MRI Brain Volume % Changes Over 48 mo
MRI Lesions at Baseline	WB	WM	GM	Cortical	Lateral Ventricle	SDGM	Thalamus
T2 LV	0.001^{^b}	.001^{^b}	<.001^{^b}	.004^{^b}	<.001^{^b}	.133	<.001^{^b}
T2 LN	.010^{^b}	.001^{^b}	<.001^{^b}	<.001^{^b}	<.001^{^b}	.243	<.001^{^b}
CE positivity	<.001^{^b}	.007^{^b}	.004^{^b}	.002^{^b}	<.001^{^b}	.292	.517
CE LN	<.001^{^b}	<.001^{^b}	<.001^{^b}	<.001^{^b}	<.001^{^b}	.029^{^b}	.018^{^b}
CE LV	<.001^{^b}	.001^{^b}	<.001^{^b}	<.001^{^b}	<.001^{^b}	.101	.234

Note:—WB indicates whole brain; LN, lesion number.
↵a All data are reported as P values corrected by the Benjamini–Hochberg procedure. Associations between MRI measures were tested by using mixed-model analysis.
↵b P < .05.