Table 4:

Relationship between evolution of MRI lesion and brain volumetric measures over a 48-month period^{^a}

Longitudinal MRI Lesion Measures	MRI Brain Volume % Changes Over 48 mo
Longitudinal MRI Lesion Measures	WB	WM	GM	Cortical	Lateral Ventricle	SDGM	Thalamus
Total cumulative T2 LN	<.001^{^b}	.517	.013^{^b}	.036^{^b}	.007^{^b}	.015^{^b}	.013^{^b}
T2 LV absolute change	.115	.444	.234	.456	.861	.717	.659
Total cumulative CE LN	.394	.182	.489	.795	.341	.193	.489
CE LV absolute change	.360	.936	.399	.802	.160	.769	.843

Note:—WB indicates whole brain; LN, lesion number.
↵a All data are reported as P values corrected by the Benjamini-Hochberg procedure. Associations between MRI measures were tested by using mixed-model analysis with interaction with time.
↵b P < .05.