Results of individual and multiple-variable ROCs for the diagnosis of CNSLa
| Factor and P Value | ROC Results with Optimized Thresholds | ||||
|---|---|---|---|---|---|
| AUC (95% CI) | Maximum Youden Index J | Threshold Sensitivity/Specificity | Threshold ± Likelihood Ratios | Threshold PPV/NPV | |
| ADCavg (P < .001) | 0.739 (0.634–0.827) | 0.521 at ≤971 | 90.70/61.36 | 2.35/0.15 | 69.64/87.10 |
| CXCL-13 (P < .001) | 0.832 (0.737–0.904) | 0.677 at <106.0 | 76.74/90.91 | 8.44/0.26 | 89.19/80.00 |
| IL-10 (P < .001) | 0.792 (0.692–0.872) | 0.583 at >21.77 | 62.79/95.45 | 13.81/0.39 | 93.10/72.41 |
| ADCavg, CXCL-13, IL-10 (P < .001) | 0.928 (0.851–0.972) | 0.723 at probability of >0.527 | 81.40/90.91 | 11.26/0.25 | 89.74/83.33 |
Note:—NPV indicates negative predictive value; PPV, positive predictive value.
↵a All ROC curves were statistically significant. Optimized thresholds were selected by using the maximum Youden Index J, the maximum vertical distance from the AUC = 0.5 null hypothesis line (sensitivity [1-specificity]). PPV and NPV should be interpreted with caution because they are highly dependent on the prevalence of the disease in the tested population, and as CSF testing becomes more common, this may not be reflective of our study population.