χ (ppm) ± SE | R2* (s−1) ± SE | Corrected Volume (mL) ± SE | ||||
---|---|---|---|---|---|---|
Controls | Premanifest HD | Controls | Premanifest HD | Controls | Premanifest HD | |
Caudate nucleus | 0.023 ± 0.002 | 0.048 ± 0.004a,b,c | 43.69 ± 0.88 | 49.35 ± 1.63c,d | 7.1 ± 0.8 | 5.4 ± 0.9a,b |
Putamen | 0.029 ± 0.002 | 0.067 ± 0.007a,b,c | 52.59 ± 1.39 | 64.21 ± 2.55b,c,d | 8.6 ± 0.7 | 6.1 ± 1.3a,b |
Globus pallidus | 0.091 ± 0.005 | 0.117 ± 0.007d | 84.48 ± 2.64 | 92.75 ± 3.35 | 2.8 ± 0.4 | 3.0 ± 0.8 |
Thalamus | −0.024 ± 0.002 | −0.021 ± 0.002 | 40.22 ± 0.70 | 40.07 ± 0.79 | 13.8 ± 0.8 | 12.9 ± 1.5 |
Amygdala | −0.018 ± 0.003 | −0.023 ± 0.002 | 29.82 ± 0.78 | 31.59 ± 1.64 | 1.9 ± 0.6 | 2.0 ± 0.7 |
Hippocampus | −0.017 ± 0.001 | −0.021 ± 0.002d | 31.32 ± 0.54 | 30.47 ± 1.12 | 6.1 ± 0.9 | 5.7 ± 1.1 |
Substantia nigra | 0.080 ± 0.004 | 0.057 ± 0.009e | 75.45 ± 2.68 | 70.62 ± 3.05 | 1.3 ± 0.4 | 1.3 ± 0.4 |
Red nucleus | 0.076 ± 0.005 | 0.066 ± 0.009 | 65.30 ± 2.71 | 67.00 ± 2.47 | 0.5 ± 0.2 | 0.6 ± 0.1 |
↵a Significant difference with P < .001.
↵b Significant correlation with CAPs score in subjects with premanifest HD.
↵c Significant correlation with ROI volume in subjects with premanifest HD.
↵d Significant difference with P < .01.
↵e Significant difference between controls and premanifest HD with P < .05.