Summary of all data collected for patients with connective tissue diseases who underwent MRA, CTA, or DSA imaging of the head
| Marfan | Ehlers-Danlos | NF1 | Loeys-Dietz | |
|---|---|---|---|---|
| No. of patients | 59 | 99 | 47 | 25 |
| Mean age (yr) | 49.4 | 41.7 | 38.3 | 36.5 |
| No. (%) female | 29 (49%) | 81 (82%) | 23 (49%) | 13 (52%) |
| Cerebral imaging modality | ||||
| CTA, No. (%) | 16 (27%) | 24 (24%) | 4 (9%) | 9 (36%) |
| MRA, No. (%) | 53 (90%) | 85 (86%) | 44 (94%) | 22 (88%) |
| DSA, No. (%) | 1 (2%) | 2 (2%) | 9 (19%) | 0 (0%) |
| No. (%) intracranial aneurysms | 8 (14%) | 12 (12%) | 5 (11%) | 7 (28%) |
| No. (%) multiple intracranial aneurysms | 2 (3%) | 2 (2%) | 1 (2%) | 1 (4%) |
| Total No. of aneurysms | 12 | 14 | 7 | 8 |
| Location, No. (%): | ||||
| ICA | 9 (15%) | 12 (12%) | 3 (6%) | 5 (20%) |
| MCA | 0 (0%) | 1 (1%) | 2 (4%) | 0 (0%) |
| ACA | 0 (0%) | 0 (0%) | 0 (0%) | 1 (4%) |
| AcomA | 1 (2%) | 1 (1%) | 1 (2%) | 0 (0%) |
| PCA | 2 (3%) | 0 (0%) | 0 (0%) | 0 (0%) |
| Basilar | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) |
| Vertebral | 0 (0%) | 0 (0%) | 1 (2%) | 2 (8%) |
| Other | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) |
| Mean (SD) aneurysm size (mm) | 4.4 (7.4) | 6.9 (6.5) | 11.2 (9.8) | 4.8 (4.5) |
| Other intracranial vascular findings, No. (%) | ||||
| AVM | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) |
| AVF | 1 (2%) | 2 (2%) | 0 (0%) | 0 (0%) |
| Dissection | 2 (3%) | 1 (1%) | 0 (0%) | 0 (0%) |
| Intracranial hemorrhage, No. (%) | 0 (0%) | 2 (2%) | 2 (4%) | 1 (4%) |
| Comorbidities, No. (%) | ||||
| Hypertension | 21 (36%) | 24 (24%) | 15 (32%) | 7 (28%) |
| Hyperlipidemia | 24 (41%) | 15 (15%) | 9 (19%) | 5 (20%) |
| Diabetes mellitus | 4 (7%) | 3 (3%) | 2 (4%) | 1 (4%) |
| Smoking | 23 (39%) | 32 (32%) | 14 (30%) | 11 (44%) |
| Stroke | 10 (17%) | 7 (7%) | 9 (19%) | 2 (8%) |
| Coronary artery disease | 8 (14%) | 5 (5%) | 3 (6%) | 2 (8%) |
Note:—ACA indicates anterior cerebral artery; AcomA, anterior communicating artery; PCA, posterior cerebral artery.