Table 1:

Participant demographic data, neurocognitive scores, and fractional brain volume^{^a}

	HC (n = 19)	RRMS-NI (n = 19)	RRMS-I (n = 20)
Demographics
Age (yr)	49.0 ± 7.1	46.4 ± 7.2	48.1 ± 4.7
Female sex (No.) (%)	14 (73.68)	15 (78.95)	12 (60)
Education (yr)	16.9 ± 2.9^{^b}	16.1 ± 1.3	14.6 ± 1.9^{^b}
Disease duration (yr)	0.0 ± 0.0	11.8 ± 5.4	11.6 ± 4.9
HADS-A (log) (median) (IQR)	3 (1–6)^{^b,^c}	6 (5–7)^{^c}	8 (7–10)^{^b}
HADS-D (log) (median) (IQR)	2 (1–3)^{^b}	3 (1,5)^{^d}	8 (6–10)^{^b,^d}
EDSS median (IQR)	NA	1.5 (1–2)^{^d}	2.5 (2–3)^{^d}
Percentage fractional brain volume
BPF	79 ± 9^{^b}	75 ± 6	72 ± 8^{^b}
fC	45.15 ± 5.12	43.43 ± 3.91	41.87 ± 5.50
fWM	31.66 ± 4.07^{^b}	29.61 ± 2.83	28.35 ± 3.5^{^b}
fCL	0.00 ± 0.00^{^b}	0.01 ± 0.01	0.01 ± 0.02^{^b}
fBG	1.35 ± 0.19	1.31 ± 0.18	1.25 ± 0.22
fTh	0.68 ± 0.12^{^b}	0.64 ± 0.14	0.55 ± 0.14^{^b}
fWML	0.00 ± 0.00^{^b}	0.67 ± 0.74	0.92 ± 0.90^{^b}
fT1 hole	0.00 ± 0.00^{^b}	0.23 ± 0.22	0.410 ± 0.506^{^b}
fCSF	21.16 ± 8.78^{^b}	24.10 ± 6.24	26.64 ± 7.32^{^b}

Note:—HADS indicates Hospital Anxiety [A] and Depression [D] Scale; EDSS, Extended Disability Status Scale; BPF, brain parenchymal fraction; fC, fractional cortical volume; fWM, fractional white matter volume; fCL, fractional cortical lesions volume; fBG, fractional basal ganglia volume; fTh, fractional thalamus volume; fWML, fractional white matter lesions volume; fTI hole, fractional T1 hole volume; fCSF, fractional CSF volume; HC, healthy controls; NA, not applicable; IQR, interquartile range.
↵a All values are means unless otherwise specified. Significant P value < .017.
↵b HC vs RRMS-I.
↵c HC vs RRMS-NI.
↵d RRMS-NI vs RRMS-I.